- 71 INR
- General Medicines
- NF, gelatin NF, glycerin USP, lecithin NF, titanium dioxide USP
- 100 Mg
- Cool and Dry Place
Natural Micronized Progesterone Capsule is prescribed for maintaining lining of uterus, improving premenstrual symptoms, & normalizing copper and zinc levels. It is helpful in treating symptoms associated with low progesterone levels inside body and to prevent overgrowth of uterus lining. Upon ingestion, Natural Micronized Progesterone Capsule binds to estrogen & progesterone receptors and decreases frequency of gonadotropin hormone release by hypothalamus. It is also known to assist in promoting normal cellular oxygen levels and serve as precursor to cortisone & sex hormones.
Helps in normal thyroid hormone functioning
Act as natural diuretic agent
Progesterone capsule contain micronized progesterone - female hormone important for the regulation of ovulation and menstruation. Progestin is a general term for a substance that causes some or all of the biologic effects of progesterone. Progesterone is a hormone the female body makes and needs for many health reasons.
Progesterone is synthesized from a starting material from a plant source and is chemically identical to progesterone of human ovarian origin.
Progesterone is a natural steroid hormone that is found in much higher concentrations in women than in men. It operates harmoniously with estrogen and other steroid hormones involved in physiological functions such as the menstrual cycle and preparing the uterine lining for implantation by a fertilized egg. Other vital roles of progesterone are building new bone tissues and countering the tendency of estrogen to cause excess growth in the lining of the uterus (the endometrium).
Progesterone is a precursor to the hormones estrogen and testosterone. (Estrogen is not actually a single hormone, like testosterone, but a term for a group of related female sex hormones with similar biological activity, mainly estrone, estradiol, and estriol.) If progesterone diminishes, so can these other hormones, which have their own important roles in our physiological health.
Role of Progesterone in women:
In women, the hormone estrogen stimulates growth of tissue inside the uterus. To keep the body from producing uterine overgrowth, the hormone progesterone slows this activity and boosts growth elsewhere. (It helps strengthen bone, for example.) Progesterone restricts estrogen synthesis and suppresses the enzymes that promote estrogen production. It blocks estrogen receptors and suppresses the genes that are encoded to promote estrogen production.It is also beneficially active upon breast tissue. In fact, progesterone reduces estrogen's stimulation of breast cancer growth.
Special proteins during the second half of the menstrual cycle, preparing it to receive and nourish an implanted fertilized egg. If implantation does not occur, estrogen and progesterone levels drop, the endometrium breaks down and menstruation occurs.
If a pregnancy occurs, progesterone is produced in the placenta, and levels remain elevated throughout the pregnancy. The combination of high estrogen and progesterone levels suppress further ovulation during pregnancy. Progesterone also encourages the growth of milk-producing glands in the breast during pregnancy.
High progesterone levels are believed to be partly responsible for symptoms of premenstrual syndrome (PMS), such as breast tenderness, feeling bloated and mood swings. When you skip a period, it could be because of failure to ovulate and subsequent low progesterone levels.
Progesterone is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body. It is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.
- Promotes bone building and protects against osteoporosis
- Improves premenstrual symptoms (PMS)
- Precursor of other sex hormones (estrogen and testosterone) and cortisone
- Maintains lining of uterus
- Promotes survival of the embryo and fetus throughout gestation
- Natural diuretic
- Promotes fat burning for energy (thermogenesis)
- Acts as a natural antidepressant
- Aids thyroid hormone action
- Normalizes blood clotting
- May help maintain sex drive
- Helps keep blood sugar levels normal
- Normalizes zinc and copper levels
- Promotes proper cellular oxygen levels
Mechanism of action:
Progesterone soft gel capsules are an oral dosage form of micronized progesterone which is chemically identical to progesterone of ovarian origin. The oral bioavailability of progesterone is increased through micronization. Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.
Progesterone is a naturally occuring progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. A progesterone trick the body processes into thinking that ovulation has already occurred by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.
After oral administration of progesterone as a micronized soft-gelatin capsule formulation, maximum serum concentrations were attained within 3 hours. The absolute bioavailability of micronized progesterone is not known.
Progesterone is approximately 96 percent to 99 percent bound to serum proteins, primarily to serum albumin (50 to 54 percent) and transcortin (43 to 48 percent).
Progesterone is metabolized primarily by the liver largely to pregnanediols and pregnanolones. Pregnanediols and pregnanolones are conjugated in the liver to glucuronide and sulfate metabolites. Progesterone metabolites which are excreted in the bile may be deconjugated and may be further metabolized in the intestine via reduction, dehydroxylation, and epimerization.
The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the bile and urine. Progesterone metabolites are eliminated mainly by the kidneys. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces.
Pregnancy & lactation:
Progesterone is only recommended for use during pregnancy when benefit outweighs risk.Please consult the doctor before taking this medicine.
Detectable amounts of progesterone have been identified in the milk of nursing mothers; however, the effect on the nursing infant has not been determined. Progesterone is administered to nursing mothers only when clearly necessary.
- Progesterone Capsules should not be used in patients with known hypersensitivity to its ingredients
- Undiagnosed abnormal genital bleeding
- Known, suspected, or history of breast cancer
- Active deep vein thrombosis, pulmonary embolism or history of these conditions
- Active arterial thromboembolic disease (for example, stroke and myocardial infarction), or a history of these conditions
- Known liver dysfunction or disease
Warning & Precaution:
This has been prescribed for the patient's specific condition. It may be dangerous to any other person.
Like almost all medications, hormone therapy has side effects. The most common side effects are:
- Monthly bleeding (if progestin given cyclical)
- Irregular spotting
- Breast tenderness
- Fluid retention
- Headaches (including migraine)
- Skin discoloration (brown or black spots)
- Increased breast density making mammogram interpretation more difficult
- Skin irritation under estrogen patch
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